Roger Federer begins his quest for a record-extending ninth Wimbledon men’s singles title when the 2018 tournament begins on Monday.
The Swiss great, 36, opens against Serbia’s Dusan Lajovic on Centre Court from 13:00 BST.
Seven-time champion Serena Williams, back at SW19 for the first time since giving birth, also plays on Monday.
The Scot initially looked set to feature after saying he was most likely to be fit enough to continue his comeback from almost a year out with a hip injury.
The 31-year-old returned at Queen’s last month, losing to Nick Kyrgios.
Murray, who won Wimbledon in 2013 and 2016, then took a wildcard at Eastbourne. There he beat fellow three-time Grand Slam champion Stan Wawrinka before losing to compatriot Edmund.
However, he was concerned about his long-term fitness and felt Wimbledon simply came “too soon”.
“It is with a heavy heart that I’ll be withdrawing from Wimbledon this year,” Murray said.
During his 11 months out, Murray has been replaced by Edmund as the British number one.
The 23-year-old Yorkshireman has broken into the world’s top 20 after reaching the semi-finals of the Australian Open.
However, the world number 18 has only won one main-draw match at Wimbledon, reaching round two last year.
The 22-year-old has enjoyed a memorable breakthrough year, which started with an epic win on his Davis Cup debut, continued with his first ATP semi-final, and resulted in a ranking of 79.
Federer is the favourite after moving clear of Pete Sampras with victory last year.
He decided to skip the clay-court season again, returning triumphantly at the Stuttgart Open.
Federer looked on course to continue his unbeaten run at Halle last week, but lost in the final to Borna Coric.
That meant Nadal, fresh from winning his 16th Grand Slam and 11th French Open, regained the number one ranking.
Nadal, 32, and Federer have won the past six Grand Slams between them.
Novak Djokovic: The three-time champion is working his way back after a year disrupted by an elbow injury but showed glimpses of his best form at the French Open and Queen’s.
Marin Cilic: The Croat is a proven force on grass, having reached last year’s final and won Queen’s last month.
Alexander Zverev: Only Federer and Nadal have outperformed the 21-year-old this year.
Dominic Thiem: The Austrian reached his first major final on his favoured surface at Roland Garros.
Seeded Serena is back
Williams missed last year’s tournament as she was pregnant with her first child. She returns amid controversy about whether she should have been seeded.
The 36-year-old American has been given the 25th seed, a decision world number 32 Dominika Cibulkova – who has made way – described as unfair.
Williams, who has not lost a singles match at Wimbledon since 2014, has only played four events since returning after giving birth to daughter Alexis in September.
“You can never underestimate a champion like her,” said Wimbledon champion GarbineMuguruza.
Wimbledon 2017: Johanna Konta beats Simona Halep – highlights
British number one Konta reached the semi-finals at the All England Club last year.
That helped the 27-year-old climb to a career-high fourth in the rankings, but she has since fallen to 22nd.
“I’m really excited to be back,” she said.